dynamic light scattering protein aggregation

Dynamic light scattering protein aggregation pdf#
Dynamic light scattering protein aggregation software#

The new DynaPro Plate Reader III excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS measurements.

Dynamic light scattering protein aggregation pdf#

Data files and concise PDF reports can be stored on the instrument, transferred via the network or downloaded to a flash drive. It tells if the data quality is sufficient for confidence in the results, and displays them instantly. via the full-size touch screen display, DYNAMICS Touch guides user through the entire setup and measurement process. DYNAMICS Touch is an intuitive - yet capable DLS measurement app that resides right on the NanoStar. The NanoStar is the only DLS instrument to provide a fully integrated, walk-up measurement experience. Walk-up operation with DYNAMICS ® Touch ™

Dynamic light scattering protein aggregation software#

21 CFR Part 11 compliance with host PC and DYNAMICS software.

Connects to DAWN, miniDAWN for online DLS.

Broadest temperature control : -10 Deg C to +120 Deg C with fast ramping.

Proven SLS technology complementing the DLS.

Dynamics®Touch® on-board app for instant measurements.

Just 2 µL in quartz/ 4 µL in specially designed disposable cuvette.

Measure size, molar mass, particle concentration & stability, all in one!.

In addition to the SPCM-based DLS detection channel, the NanoStar II incorporates a separate, optimized SLS detection channel featuring a highly linear, low noise photodiode - in fact, the same photodiode used in the Wyatt’s highly renowned on-line multi-angle light scattering (MALS) detectors. The NanoStar utilizes a temperature-stabilized APD coupled to an advanced double density, multi-tau (DDMT) correlator for analysis of diffusion coefficients, size and size distributions. The DynaPro ® NanoStar ®II is a unique cuvette-based DLS instrument used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, liposomes, lipid and metallic nanoparticles, and more.

Measure viscosity of concentrated biotherapeutics with just a few microliters of solution.

Assess colloidal stability as a precursor to aggregation and precipitation.

Quantify self-assembly processes of polypeptides or DNA.

Measure size and concentration of viruses and VLPs.Analyze thermal stability and chemical denaturation, differentiating pure unfolding from aggregation.Check quality of biomolecules prior to running costly analyses such as SPR or SANS.Estimate populations of aggregates large and small, for small molecules, proteins or liposomes.Here are just a few of the diverse applications supported by DLS: Wyatt offers high-throughput, automated DLS as well as conventional, cuvette-based formats. Sizes and size distributions, in turn, are calculated from the diffusion coefficients in terms of hydrodynamic radius R h or hydrodynamic diameter d h.DLS is suitable for ensemble measurements ranging from R h values of 0.2 nm up to 5,000 nm. Dynamic Light Scattering (DLS) measures the translational diffusion coefficients D t of nanoparticles and colloids in solution by quantifying dynamic fluctuations in scattered light.